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SLC7A11 inhibition results in GSH depletion, which downregulates GPX4 levels, thereby promoting cellular/subcellular membrane damage caused by LPOs [28]

However, most of this research has been conducted in animal models, and human safety and efficacy data are limited

DA is a strong modulator of prefrontal activity and increases excitability of pyramidal cells in response to depolarization via D1 receptors [101]

This cascade leads to a significant increase in TFR1 and Fe 2+ levels, promoting neuronal ferroptosis and lipid peroxidation, which exacerbates muscle atrophy and motor dysfunction in mice

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